Mr. Skullhead is a character imagined by Elmyra Duff from the skull she wears in the middle of her bow. He appears in sketches in the episodes, Take Elmyra Please, Grandma's Dead, and Weekday Afternoon Live. He is also mentioned in Toons from the Crypt, when Buster, as the Cryptkeeper, plays with an Elmyra voodoo doll. He would later become a recurring character on Animaniacs, notably in the Good Idea, Bad Idea sketches, in which he and his family would be horribly maimed.
- Mr. Skullhead was designed by Tiny Toons writer, Sherri Stoner.