Ed is an elderly human with comb-back white hair wearing a gray shirt with a white undershirt and black bow tie.
His first appearance is in the episode "Hog Wild Hamton". He appears in an Acme Clearinghouse commercial where he tells the viewers that they can win large amounts of money by finding his face on letters in their mailbox. To get these kinds of letters, they must subscribe to thousands of overpriced magazines. He later appears at the end of the episode when he arrives in his limo and tells Hamton that he is Acme Clearinghouse's grand prize winner and won a new house. After Hamton and his parents go into their new home, Egghead Junior arrives and hands Ed a note telling him that he is studying for a very important test and requests that he stop laughing. Ed continues to laugh and Egghead Junior pokes him in the belly button, causing him pain.
Ed McMayhem makes a cameo appearance in the episode, "The Return of Batduck", where he stars in the show Practical Pranks and Goof-ups alongside Dick Clark. They both comment on Plucky going into a Batman-themed bathroom, then they each get hit by a falling anvil.
- Ed McMayhem is a parody of the late Ed McMahon, who is best known as an American comedian, game show host, announcer, and sidekick to Johnny Carson. He also presented sweepstakes for the direct marketing company American Family Publishers.